RAB11A Antibody, HRP conjugated - Cat. #: CSB-PA019153HB01HU

SKU: CSB-PA019153HB01HU

Size :50ug

Clone Number:

Aliases:MGC1490 antibody; Rab 11 antibody; Rab 11A antibody; RAB 11A, member oncogene family antibody; Rab-11 antibody; RAB11 A antibody; RAB11 antibody; Rab11a antibody; RAB11A member RAS oncogene family antibody; Ras related protein Rab 11A antibody; Ras related protein Rab11A antibody; Ras-related protein Rab-11A antibody; RB11A_HUMAN antibody; YL 8 antibody; YL8 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P62491

Immunogen:Recombinant Human Ras-related protein Rab-11A protein (2-213AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RAB11A

Research Areas:Cancer; Signal transduction