Rab 3 GAP p130 rabbit pAb

SKU: ES3288

Size: 100μL

Source:Rabbit

Applications:WB;IHC;IF;ELISA

Reactivity:Human;Rat;Mouse;

Dilution:Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Immunogen:The antiserum was produced against synthesized peptide derived from human RAB3GAP1. AA range:538-587

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):117kD

Human_gene_id:22930

Human_swiss_prot_no:Q15042

Subcellular_location:Cytoplasm . In neurons, it is enriched in the synaptic soluble fraction.

Other_name:RAB3GAP1; KIAA0066; RAB3GAP; Rab3 GTPase-activating protein catalytic subunit; RAB3 GTPase-activating protein 130 kDa subunit; Rab3-GAP p130; Rab3-GAP

Background:This gene encodes the catalytic subunit of a Rab GTPase activating protein. The encoded protein forms a heterodimer with a non-catalytic subunit to specifically regulate the activity of members of the Rab3 subfamily of small G proteins. This protein mediates the hydrolysis of GTP bound Rab3 to the GDP bound form. Mutations in this gene are associated with Warburg micro syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010],