pVHL Polyclonal Antibody

SKU: E-AB-10671

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:VHL

Target Synonym:Elongin binding protein;G7 protein;HRCA 1;HRCA1;Protein G7;pVHL;RCA 1;RCA1;VHL 1;VHL;VHL;VHL1;VHLH;Von Hippel Lindau disease tumor suppressor;von Hippel Lindau syndrome;von Hippel Lindau tumor suppressor;Von Hippel Lindau tumor suppressor;E3 ubiquitin protein ligase;Von Hippel-Lindau disease tumor suppressor

Research Areas:Cancer;Cell Biology;Epigenetics and Nuclear Signaling;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P40337

Accession:

Background:Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Concentration:0.4 mg/mL

Immunogen:Recombinant protein of human VHL

Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method:Affinity purification

Dilution:IHC 1:50-1:200

Calculated MW:

ObservedMW: