PTPRU Monoclonal Antibody

SKU: BT-MCA4266

Size:100μL

Background:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported.

Research_area:Signal transduction

Target_protein:PTPRU

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:1A6E5

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:PTPRU

Immunogen:Purified recombinant fragment of human PTPRU (AA: extra 579-749) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):162.4kDa

UniProt accession:Q92729

Synonyms:FMI, PTP, PCP-2, PTP-J, PTPRO, PTPU2, PTP-PI, PTP-RO, PTPPSI, hPTP-J, R-PTP-U, R-PTP-PSI

GeneID:10076