PTK6 Monoclonal Antibody

SKU: BT-MCA2986

Size:100μL

Background:PTK6 (protein tyrosine kinase 6, BRK or FLJ42088), with 451-amino acid protein (about 52kDa), encods a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Its presence in the nucleus appears to be linked to suppression of tumor progression. The encoded protein has been shown to undergo autophosphory-lation. Very high level in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. And Expressed at low level in some breast tumors, but not in normal breast. Also found in melanocytes, but not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype.

Research_area:Signal Transduction

Target_protein:PTK6

applications:WB

Reactivity:Human

Clonality:Monoclonal

Clone ID:2H12B8

Host:Mouse

Isotype:Mouse IgG2b

Gene Symbol/ Name:PTK6

Immunogen:Purified recombinant fragment of human PTK6 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):52kDa

UniProt accession:Q13882

Synonyms:BRK, FLJ42088

GeneID:5753