PTK2B Polyclonal Antibody

SKU: E-AB-11212

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:PTK2B

Target Synonym:CADTK;CAK-beta;CAKB;CAKbeta;Calcium regulated non receptor proline rich tyrosine kinase;Calcium-dependent tyrosine kinase;Cell adhesion kinase beta;E430023O05Rik;EC 2.7.10.2;FADK 2;FADK2;FAK2;FAK2;Focal adhesion kinase 2;MGC124628;PKB;Proline-rich tyrosine kinase 2;Protein kinase B;Protein Tyrosine Kinase 2 Beta;Protein-tyrosine kinase 2-beta;PTK;PTK2B;PTK2B protein tyrosine kinase 2 beta;PYK2;RAFTK;RAFTK2;Related adhesion focal tyrosine kinase

Research Areas:Cancer;Metabolism;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q14289

Accession:

Background:This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Concentration:0.6 mg/mL

Immunogen:Recombinant protein of human PTK2B

Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method:Affinity purification

Dilution:IHC 1:50-1:200

Calculated MW:

ObservedMW: