PSME1 Rabbit Polyclonal Antibody

SKU: BT-AP04321

Size:100μL

Background:The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes| a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base| which contains 6 ATPase subunits and 2 non-ATPase subunits| and a lid| which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome| the immunoproteasome| is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator| referred to as the 11S regulator or PA28| that replaces the 19S regulator. Three subunits (alpha| beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator| one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants.

Research_area:Cell biology; Microbiology

Target_protein:PSME1

applications:WB

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:PSME1

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):27390

UniProt accession:Human: Q06323; Mouse: P97371; Rat: Q63797

Synonyms:PSME1

GeneID:Human: 5720; Mouse: 19186