Porcine Scavenger Receptor Cysteine-rich Type 1 Protein M130, CD163 ELISA Kit

SKU: E0602Po

Size:96 Tests-1 Kit

Background:Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). May play a role in the process of infection of porcine monocytes/macrophages by African swine fever virus (ASFV). In case of porcine reproductive and respiratory syndrome virus (PRRSV), serves mediates virion attachment and plays a role in viral entry. After shedding, the soluble form (sCD163) may play an anti-inflammatory role.

Research_area:Immunology

Applications:ELISA

Target_protein:CD163

Reactivity:Porcine

Assay type:Sandwich

Sensitivity:24.97ng/mL

Detection range:50-10000ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Scavenger Receptor Cysteine-Rich Type 1 Protein M130

Species:Porcine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q2VL90

MASS(Da):120,456

GeneID:397031

Synonyms:CD 163;CD antigen CD163;CD163;Scavenger receptor cysteine-rich type 1 protein M130;sCD163;Soluble CD163

Gene names:CD163

Standard solution:12800ng/mL