Porcine Prostaglandin reductase 1,PTGR1 ELISA KIT

SKU: E0369Po

Size:96 Tests-1 Kit

Background:NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:8576264, PubMed:9461497, PubMed:10837478, PubMed:11688989). Preferentially uses NADPH over NADH as cofactor (PubMed:9461497). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed:9461497, PubMed:11688989). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (PubMed:8576264, PubMed:8394361). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4 and may promote neutrophil recruitment at the inflammatory site (PubMed:10837478, PubMed:11688989). Plays a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (By similarity). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity). {ECO:0000250|UniProtKB:P97584, ECO:0000250|UniProtKB:Q14914, ECO:0000269|PubMed:10837478, ECO:0000269|PubMed:11688989, ECO:0000269|PubMed:8394361, ECO:0000269|PubMed:8576264, ECO:0000269|PubMed:9461497}.

Research_area:

Applications:ELISA

Target_protein:PTGR1

Reactivity:Porcine

Assay type:Sandwich

Sensitivity:0.29ng/ml

Detection range:0.5-32ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Prostaglandin reductase 1

Species:Porcine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q29073

MASS(Da):35762

GeneID:397678

Synonyms:PTGR1 LTB4DH

Gene names:PTGR1

Standard solution:64ng/ml