PLEKHG6 Antibody - Cat. #: CSB-PA212466

SKU: CSB-PA212466

Size :50ul

Clone Number:

Aliases:PLEKHG6 antibody; Pleckstrin homology domain-containing family G member 6 antibody; PH domain-containing family G member 6 antibody; Myosin-interacting guanine nucleotide exchange factor antibody; MyoGEF antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q3KR16

Immunogen:Fusion protein of Human PLEKHG6

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC; ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

Background:PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PLEKHG6

Research Areas:Cancer;Cell biology;Signal transduction