PLCG2 Monoclonal Antibody

SKU: BT-MCA2036

Size:100μL

Background:The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.

Research_area:Cardiovascular

Target_protein:PLCG2

applications:WB, ICC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:3A8B6

Host:Mouse

Isotype:Mouse IgG2b

Gene Symbol/ Name:PLCG2

Immunogen:Synthesized peptide of human PLCG2 (AA: phospho-Tyrosine 753 of human Phospholipase Cg2(cERDINSLpYDVSRMYV)).

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide.

Concentration:

Molecular weight(Da):148kDa

UniProt accession:P16885

Synonyms:FCAS3, APLAID, PLC-IV, PLC-gamma-2

GeneID:5336