Pirh2 Monoclonal Antibody

SKU: BT-MCA4310

Size:100μL

Background:Pirh 2 (P53 induced RING-H2 protein), also known as RCHY1, it forms dimers through its N- and C-terminus in cells. The Pirh2 has ubiquitin-protein ligase activity and it binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. The Pirh2 is oncogenic because loss of p53 function contributes directly to malignant tumor development. Pirh2 expression decreases the level of p53, and a decrease of endogenous Pirh2 expression increases p53 levels. Pirh2 is therefore considered, together with MDM2, to act as a negative regulator of p53 function.

Research_area:Others

Target_protein:Pirh2

applications:WB, IHC, ICC, FCM

Reactivity:Human, Rat

Clonality:Monoclonal

Clone ID:1H10

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:Pirh2

Immunogen:Purified recombinant fragment of human Pirh2 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):30kDa; 60kDa (homodimer)

UniProt accession:Q96PM5

Synonyms:ARNIP, CHIMP, RNF199, RCHY1

GeneID:25898