PIN1 Antibody, Biotin conjugated - Cat. #: CSB-PA04619D0Rb

SKU: CSB-PA04619D0Rb

Size :50ug

Clone Number:

Aliases:DOD antibody; DODO, Drosophila, homolog of antibody; FLJ40239 antibody; FLJ77628 antibody; MGC10717 antibody; NIMA interacting 1 antibody; Peptidyl prolyl cis trans isomerase NIMA interacting 1 antibody; Peptidyl prolyl cis/trans isomerase NIMA interacting antibody; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody; Peptidyl-prolyl cis-trans isomerase pin1 antibody; Peptidylprolyl cis/trans isomerase NIMA interacting 1 antibody; Pin 1 antibody; Pin1 antibody; PIN1_HUMAN antibody; PPIase Pin1 antibody; Prolyl isomerase antibody; Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1 antibody; Protein NIMA interacting 1 antibody; Rotamase Pin1 antibody; UBL 5 antibody; UBL5 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q13526

Immunogen:Recombinant Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 protein (1-163AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PIN1

Research Areas:Neuroscience; Cell biology