Phospho-STAT1 (Tyr701) Antibody - Cat. #: CSB-PA926759

SKU: CSB-PA926759

Size :100ul

Clone Number:

Aliases:Signal transducer and activator of transcription 1 91kD antibody; CANDF7 antibody; DKFZp686B04100 antibody; IMD31A antibody; IMD31B antibody; IMD31C antibody; ISGF 3 antibody; ISGF-3 antibody; OTTHUMP00000163552 antibody; OTTHUMP00000165046 antibody; OTTHUMP00000165047 antibody; OTTHUMP00000205845 antibody; Signal transducer and activator of transcription 1 91kDa antibody; Signal transducer and activator of transcription 1 antibody; Signal transducer and activator of transcription 1, 91kD antibody; Signal transducer and activator of transcription 1-alpha/beta antibody; STAT 1 antibody; Stat1 antibody; STAT1_HUMAN antibody; STAT91 antibody; Transcription factor ISGF 3 components p91 p84 antibody; Transcription factor ISGF-3 components p91/p84 antibody; Transcription factor ISGF3 components p91/p84 antibody; XStat1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P42224

Immunogen:Peptide sequence around phosphorylation site of tyrosine 701 (T-G-Y(p)-I-K) derived from Human STAT1.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; WB:1:500-1:1000, IHC:1:50-1:100

Background:

Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-a and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.

Heim M H, (1999) J Recept Signal Transduct Res. 19: 75-120.
Durbin J E, et al. (1996) Cell. 84: 443-450.
Meraz M A, et al. (1996) Cell. 84: 431-442.
Wakao H, et al. (1994) EMBO J. 13: 2182-2191.
Demoulin J, B. et al. (1999) J Biol Chem. 274: 25855-258
Ihle J N, et al. (1994) Trends Biochem Sci. 19: 222-227.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:STAT1

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Signal transduction