Phospho-PDCD4 (Ser67) Antibody - Cat. #: CSB-PA047784

SKU: CSB-PA047784

Size :100ul

Clone Number:

Aliases:Death up-regulated gene protein antibody; Dug antibody; H731 antibody; Ma3 antibody; MGC33046 antibody; MGC33047 antibody; Neoplastic transformation inhibitor antibody; Neoplastic transformation inhibitor protein antibody; Nuclear antigen H731 antibody; Nuclear antigen H731 like antibody; Nuclear antigen H731 like protein antibody; Nuclear antigen H731-like antibody; PDCD 4 antibody; Pdcd4 antibody; PDCD4_HUMAN antibody; Programmed cell death 4 antibody; programmed cell death 4 (neoplastic transformation inhibitor) antibody; Programmed cell death protein 4 antibody; Protein 197/15a antibody; Protein MA-3 antibody; Tis antibody; Topoisomerase-inhibitor suppressed protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q53EL6

Immunogen:Peptide sequence around phosphorylation site of serine 67 (K-N-S(p)-S-R) derived from Human PDCD4 .

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA

Kakade D, Islam N, Maeda N, Adegoke OA (2014)BMC Cell Biol 15, 2 . Dorrello NV, et al. (2006)Science 314, 467-71. Palamarchuk A, et al. (2005)Cancer Res 65, 11282-6.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PDCD4

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology