Phospho-NTRK1 (Tyr757) Antibody - Cat. #: CSB-PA271642

SKU: CSB-PA271642

Size :100ul

Clone Number:

Aliases:gp140trk antibody; High affinity nerve growth factor receptor antibody; High affinity nerve growth factor receptor precursor antibody; MTC antibody; Neurotrophic tyrosine kinase receptor type 1 antibody; NTRK1 antibody; NTRK1_HUMAN antibody; Oncogene TRK antibody; p14-TrkA antibody; p140 TrkA antibody; p140-TrkA antibody; Slow nerve growth antibody; Trk A antibody; TRK antibody; Trk-A antibody; TRK1 antibody; TRK1-transforming tyrosine kinase protein antibody; Tropomyosin-related kinase A antibody; Tyrosine kinase receptor A antibody; Tyrosine kinase receptor antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P04629

Immunogen:Peptide sequence around phosphorylation site of tyrosine 757 (E-V-Y(p)-A-I) derived from Human Trk A.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, IHC; IHC:1:50-1:100

Background:

Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

Martin-Zanca D., Mol. Cell. Biol. 9:24-33(1989).
Shelton D.L., J. Neurosci. 15:477-491(1995).
The MGC Project Team, Genome Res. 14:2121-2127(2004).

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NTRK1

Research Areas:Others