Phospho-NTRK1 (Tyr680/681) Antibody - Cat. #: CSB-PA095633

SKU: CSB-PA095633

Size :100ul

Clone Number:

Aliases:gp140trk antibody; High affinity nerve growth factor receptor antibody; High affinity nerve growth factor receptor precursor antibody; MTC antibody; Neurotrophic tyrosine kinase receptor type 1 antibody; NTRK1 antibody; NTRK1_HUMAN antibody; Oncogene TRK antibody; p14-TrkA antibody; p140 TrkA antibody; p140-TrkA antibody; Slow nerve growth antibody; Trk A antibody; TRK antibody; Trk-A antibody; TRK1 antibody; TRK1-transforming tyrosine kinase protein antibody; Tropomyosin-related kinase A antibody; Tyrosine kinase receptor A antibody; Tyrosine kinase receptor antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P04629

Immunogen:Peptide sequence around phosphorylation site of tyrosine 680/tyrosine 681 (T-D-Y(p)-Y(p)-R-V) derived from Human Trk A.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:

Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

Liu HY, et al. (2005) J Biol Chem 280, 19461-71
Wahab NA, Weston BS, Mason RM (2005) J Am Soc Nephrol 16, 340-51
Marsh HN, et al. (2003) J Cell Biol 163, 999-1010

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NTRK1

Research Areas:Others