Phospho-ERK 1/2 (Tyr222/205) Monoclonal Antibody

SKU: E-AB-51039

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Acetyl/Phospho/Methyl Antibodies

Abbreviation: Phospho-ERK 1/2 (Tyr222/205)

Target Synonym: MAPK3;ERK1;PRKM3;Mitogen-activated protein kinase 3;MAP kinase 3;MAPK 3;ERT2;Extracellular signal-regulated kinase 1;ERK-1;Insulin-stimulated MAP2 kinase;MAP kinase isoform p44;p44-MAPK;Microtubule-associated protein 2 kinase;p

Research Areas: Cancer;Signal Transduction;Neuroscience

Conjugation: Unconjugated

Host: Mouse

Species reactivity: Human;Mouse;Rat

Application: IHC-p

Isotype: IgG

Clonality: Monoclonal

Clone NO.: Clone:4D4

UNIProt ID: P27361,P28482

Accession:

Background: Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.

Concentration: 1mg/mL

Immunogen: Synthetic Peptide of Phospho-ERK 1/2 (Tyr222/205)

Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Purification method: Protein A purification

Dilution: IHC 1:100-200

Calculated MW:

ObservedMW: