Phospho-CDH5 (Tyr731) Antibody - Cat. #: CSB-PA868788

SKU: CSB-PA868788

Size :100ul

Clone Number:

Aliases:7B 4 antibody; 7B4 antibody; 7B4 antigen antibody; CADH5_HUMAN antibody; Cadherin 5 antibody; Cadherin 5 type 2 antibody; Cadherin 5, type 2 (vascular endothelium) antibody; Cadherin 5, type 2, VE cadherin (vascular epithelium) antibody; cadherin, vascular endothelial antibody; cadherin, vascular endothelial, 1 antibody; Cadherin-5 antibody; Cadherin5 antibody; CD 144 antibody; CD144 antibody; CD144 antigen antibody; CDH 5 antibody; CDH5 antibody; CDH5 protein antibody; Endothelial specific cadherin antibody; FLJ17376 antibody; OTTHUMP00000174777 antibody; Vascular endothelial cadherin antibody; Vascular epithelium cadherin antibody; VE Cad antibody; VE-cadherin antibody; VEC antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P33151

Immunogen:Peptide sequence around phosphorylation site of Tyrosine731 (H-I-Y(p)-G-Y) derived from Human VE-Cadherin.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen.

Wessel F, et al. (2014) Nat Immunol 15, 223-30
Sawada J, et al. (2012) Cancer Cell 22, 235-49
Turowski P, et al. (2008) J Cell Sci 121, 29-37

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CDH5

Research Areas:Cancer?Cardiovascular;Signal transduction