PDK4 Antibody, FITC conjugated - Cat. #: CSB-PA614983LC01HU

SKU: CSB-PA614983LC01HU

Size :50ug

Clone Number:

Aliases:[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4 antibody; FLJ40832 antibody; mitochondrial antibody; Pdk4 antibody; PDK4_HUMAN antibody; Pyruvate dehydrogenase [lipoamide] kinase isozyme 4 mitochondrial antibody; Pyruvate dehydrogenase kinase 4 antibody; Pyruvate dehydrogenase kinase isoenzyme 4 antibody; Pyruvate dehydrogenase kinase isoform 4 antibody; Pyruvate dehydrogenase kinase isozyme 4 antibody; Pyruvate dehydrogenase kinase isozyme 4 mitochondrial antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q16654

Immunogen:Recombinant Human [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial protein (143-333AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PDK4

Research Areas:Cancer; Metabolism; Signal transduction