PDE9A antibody , Cat. # FNab06263

SKU: FNab06263

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP(PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart(PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein(Probable). In brain, involved in cognitive function, such as learning and long-term memory(By similarity).

Immunogen:phosphodiesterase 9A

Synonyms:HSPDE9A2, PDE9A, phosphodiesterase 9A

Observed MW:

Uniprot ID:O76083

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, IF, IHC

Recommended dilution:IHC: 1:100-1:200; IF: 1:50-1:500

Gene ID:5152

Research Area:Signal Transduction, Metabolism