PCDA6 rabbit pAb

SKU: ES14235

Size: 100μL

Source:Rabbit

Applications:WB

Reactivity:Human;Rat;Mouse;

Dilution:WB 1:500-2000

Immunogen:Synthesized peptide derived from human PCDA6 AA range: 459-509

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):105kD

Human_gene_id:56142

Human_swiss_prot_no:Q9UN73

Subcellular_location:[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .

Other_name:Protocadherin alpha-6 (PCDH-alpha-6)

Background:This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008],