PAX5 Monoclonal Antibody

SKU: BT-MCA4635

Size:100μL

Background:This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

Research_area:Neuroscience

Target_protein:PAX5

applications:IHC

Reactivity:Human

Clonality:Monoclonal

Clone ID:7D3

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:PAX5

Immunogen:Purified recombinant fragment of human PAX5 (AA: 235-382) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):45kDa

UniProt accession:Q02548

Synonyms:BSAP

GeneID:5079