P4HB Antibody, Biotin conjugated - Cat. #: CSB-PA823188YD01DXU

SKU: CSB-PA823188YD01DXU

Size :50ug

Clone Number:

Aliases:P4HB antibody; PDIA1Protein disulfide-isomerase antibody; PDI antibody; EC 5.3.4.1 antibody; Prolyl 4-hydroxylase subunit beta antibody; p58 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Cricetulus griseus

UniProt ID:Q8R4U2

Immunogen:Recombinant Cricetulus griseus Protein disulfide-isomerase protein (20-509AA)

Raised in:Rabbit

Species Reactivity:Cricetulus griseus

Tested Applications:ELISA

Background:This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:P4HB

Research Areas:Others