OLIG2 Monoclonal Antibody

SKU: BT-MCA4423

Size:100μL

Background:This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.

Research_area:Epigenetics and nuclear signaling, Neuroscience, Stem cells

Target_protein:OLIG2

applications:IHC, ICC

Reactivity:Human

Clonality:Monoclonal

Clone ID:1G11

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:OLIG2

Immunogen:Purified recombinant fragment of human OLIG2 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):32kDa

UniProt accession:Q13516

Synonyms:BHLHB1, OLIGO2, RACK17, PRKCBP2, bHLHe19, OLIG2

GeneID:10215