NPRL2 Polyclonal Antibody

SKU: E-AB-16658

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: NPRL2

Target Synonym: 2810446G01Rik;G21 protein;Gene 21 protein;Homologous to yeast nitrogen permease (candidate tumor suppressor);Homologous to yeast nitrogen permease;Nitrogen permease regulator 2-like protein;Nitrogen permease regulator-like 2 (S. cerevisiae);NPR 2L;NPR L2;NPR like 2;NPR2;NPR2 like;NPR2-like protein;NPR2L;NPRL 2;NPRL2;NPRL2;Tumor suppressor candidate 4;TUSC 4;TUSC 4 protein;TUSC4;TUSC4 protein

Research Areas: Cancer;Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q8WTW4

Accession:

Background: NPRL2, also known as TUSC4 (tumor suppressor candidate 4), is a 380 amino acid protein that contains a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver and pancreas, with lower expression in lung, kidney, placenta and heart. NPRL2 is also expressed in most lung cancer cell lines and may be involved in tumor suppression. NPRL2 may play a role in mismatch repair, cell cycle checkpoint signaling and activation of apoptotic pathways. It may also enhance the therapeutic efficacy of chemotherapy drugs such as cis-platin by resensitizing patients resistant to cisplatin treatment. The gene encoding NPRL2 is conserved between species and is expressed as two isoforms due to alternative splicing events.

Concentration: 0.9 mg/mL

Immunogen: Synthetic peptide of human NPRL2

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Dilution: IHC 1:50-1:200

Calculated MW:

ObservedMW: