NPRL2 Antibody - Cat. #: CSB-PA127552

SKU: CSB-PA127552

Size :50ul

Clone Number:

Aliases:2810446G01Rik antibody; G21 protein antibody; Gene 21 protein antibody; Homologous to yeast nitrogen permease (candidate tumor suppressor) antibody; Homologous to yeast nitrogen permease antibody; Nitrogen permease regulator 2-like protein antibody; Nitrogen permease regulator-like 2 (S. cerevisiae) antibody; NPR 2L antibody; NPR L2 antibody; NPR like 2 antibody; NPR2 antibody; NPR2 like antibody; NPR2-like protein antibody; NPR2L antibody; NPRL 2 antibody; NPRL2 antibody; NPRL2_HUMAN antibody; Tumor suppressor candidate 4 antibody; TUSC 4 antibody; TUSC 4 protein antibody; TUSC4 antibody; TUSC4 protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8WTW4

Immunogen:Synthetic peptide of Human NPRL2

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC; ELISA:1:2000-1:5000, WB:1:200-1:1000, IHC:1:50-1:200

Background:NPRL2, also known as TUSC4 (tumor suppressor candidate 4), is a 380 amino acid protein that contains a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver and pancreas, with lower expression in lung, kidney, placenta and heart. NPRL2 is also expressed in most lung cancer cell lines and may be involved in tumor suppression. NPRL2 may play a role in mismatch repair, cell cycle checkpoint signaling and activation of apoptotic pathways. It may also enhance the therapeutic efficacy of chemotherapy drugs such as cis-platin by resensitizing patients resistant to cisplatin treatment. The gene encoding NPRL2 is conserved between species and is expressed as two isoforms due to alternative splicing events.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NPRL2

Research Areas:Epigenetics and Nuclear Signaling;Cancer