NPHP4 Antibody, FITC conjugated - Cat. #: CSB-PA015987LC01HU

SKU: CSB-PA015987LC01HU

Size :50ug

Clone Number:

Aliases:KIAA0673 antibody; Nephrocystin-4 antibody; nephronophthisis 4 antibody; Nephroretinin antibody; NPHP4 antibody; NPHP4_HUMAN antibody; POC10 antibody; POC10 centriolar protein homolog antibody; SLSN4 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O75161

Immunogen:Recombinant Human Nephrocystin-4 protein (397-543AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NPHP4

Research Areas:Cell biology; Signal transduction