NOTCH4 Monoclonal Antibody

SKU: BT-MCA3673

Size:100μL

Background:This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Research_area:Epigenetics and Nuclear Signaling

Target_protein:NOTCH4

applications:IHC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:6D8D4

Host:Mouse

Isotype:Mouse IgG2a

Gene Symbol/ Name:NOTCH4

Immunogen:Purified recombinant fragment of human NOTCH4 (AA: extra 118-357) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):209.6kDa

UniProt accession:Q99466

Synonyms:INT3

GeneID:4855