NOTCH3 antibody , Cat. # FNab05800

SKU: FNab05800

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain(NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs(By similarity).

Immunogen:Notch homolog 3

Synonyms:CADASIL, CASIL, Notch 3, Notch homolog 3, NOTCH3

Observed MW:250-260 kDa, 100 kDa

Uniprot ID:Q9UM47

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IHC, IP

Recommended dilution:WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:50-1:500

Gene ID:4854

Research Area:Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology