NF2 antibody , Cat. # FNab05685

SKU: FNab05685

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Probable regulator of the Hippo/SWH(Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH(Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Immunogen:neurofibromin 2(merlin)

Synonyms:SCH,ACN, BANF, Merlin, Neurofibromin 2, neurofibromin 2(merlin), NF2

Observed MW:66-70 kDa

Uniprot ID:P35240

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IHC,IP,IF

Recommended dilution:WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:50-1:500

Gene ID:4771

Research Area:Stem Cells