NF1 Polyclonal Antibody

SKU: E-AB-53528

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:NF1

Target Synonym:DKFZp686J1293;FLJ21220;Neurofibromatosis Noonan syndrome;Neurofibromatosis related protein NF 1;Neurofibromatosis related protein NF1;neurofibromatosis type I;Neurofibromatosis-related protein NF-1;Neurofibromin 1;Neurofibromin truncated;Neurofibromin1;NF 1;NF;NF1;NF1;NFNS;Type 1 Neurofibromatosis;von Recklinghausen disease neurofibromin;von Recklinghausen disease related protein VRNF;VRNF;WATS;Watson disease related protein WSS;Watson syndrome;WSS

Research Areas:Cancer;Epigenetics and Nuclear Signaling;Metabolism;Neuroscience;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P21359

Accession:

Background:This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.NF1 (Neurofibromin 1) is a Protein Coding gene. Diseases associated with NF1 include Neurofibromatosis-Noonan Syndrome and Neurofibromatosis, Type 1. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades and RET signaling. GO annotations related to this gene include binding and phosphatidylcholine binding.

Concentration:1.7 mg/mL

Immunogen:Synthetic peptide of human NF1

Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method:Antigen affinity purification

Dilution:IHC 1:40-1:250

Calculated MW:

ObservedMW: