Neurexin I rabbit pAb

SKU: ES8030

Size: 100μL

Source:Rabbit

Applications:WB;IHC

Reactivity:Human;Mouse;Rat

Dilution:WB 1:500-2000;IHC-p 1:50-300

Immunogen:The antiserum was produced against synthesized peptide derived from human NRXN1. AA range:502-551

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):150kD

Human_gene_id:9378

Human_swiss_prot_no:Q9ULB1

Subcellular_location:Cell junction, synapse, presynaptic cell membrane ; Single-pass type I membrane protein .

Other_name:NRXN1; KIAA0578; Neurexin-1-alpha; Neurexin I-alpha

Background:NRXN1 (neurexin 1) encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for NRXN1 in the 3' region. Mutations in NRXN1 are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.