NCKAP1 Antibody - Cat. #: CSB-PA295755

SKU: CSB-PA295755

Size :50ul

Clone Number:

Aliases:FLJ11291 antibody; KIAA0587 antibody; Membrane associated protein HEM2 antibody; Membrane-associated protein HEM-2 antibody; MGC8981 antibody; NAP 1 antibody; NAP1 antibody; NAP125 antibody; NCK associated protein 1 antibody; NCK associated protein antibody; Nck-associated protein 1 antibody; Nckap1 antibody; NCKP1_HUMAN antibody; OTTHUMP00000163460 antibody; OTTHUMP00000163461 antibody; p125Nap1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9Y2A7

Immunogen:Synthetic peptide of Human NCKAP1

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, IHC; ELISA:1:1000-1:2000, IHC:1:25-1:100

Background:NAP125, also known as NCKAP1 (NCK-associated protein 1), p125Nap1 or membrane-associated protein HEM-2, is a 1,128 amino acid single pass membrane protein that exists as two alternatively spliced isoforms and belongs to the HEM-1/HEM-2 family. While widely expressed, NAP125 is found at highest levels in heart, brain and skeletal muscle where it regulates Rac-dependent actin remodeling as part of a lamellipodial complex with WAVE2, Abi-1 and CYFIP1. NAP125 localizes to the cytoplasmic side of lamellipodium membrane and is encoded by a gene that maps to human chromosome 2q32.1 and mouse chromosome 2 C3. NAP125 expression is markedly reduced in Alzheimer disease (AD)-affected brains, suggesting a possible role in the disease.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NCKAP1

Research Areas:Neuroscience?Cancer;Cell biology;Signal transduction