NCAM1/CD56 antibody , Cat. # FNab05575

SKU: FNab05575

Size:100ug

Purification:Protein A+G purification

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Mouse

Clonality:monoclonal

Clone ID:0D10

Isotype:IgG2a

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Neural cell adhesion molecule 1(NCAM1, also known as CD56) is a cell adhesion glycoprotein of the immunoglobulin(Ig) superfamily. It is a multifunction protein involved in synaptic plasticity, neurodevelopment, and neurogenesis. NCAM1 is expressed on human neurones, glial cells, skeletal muscle cells, NK cells and a subset of T cells, and the expression is observed in a wide variety human tumors, including myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, and NK/T cell lymphomas. Three major isoforms of NCAM1, with molecular masses of 120, 140, and 180 kDa, are generated by alternative splicing of mRNA(PMID: 9696812). The glycosylphosphatidylinositol(GPI)-anchored NCAM120 and the transmembrane NCAM140 and NCAM180 consist of five Ig-like domains and two fibronection-type III repeats(FNIII). All three forms can be posttranslationally modified by addition of polysialic acid(PSA)(PMID: 14976519). Several other isofroms have also been described(PMID: 1856291).

Immunogen:neural cell adhesion molecule 1

Synonyms:CD56, MSK39, N CAM 1, NCAM, NCAM 1, NCAM1

Observed MW:140 kDa

Uniprot ID:P13591

Reactivity:Human, Mouse

Tested Application:ELISA, WB, IHC

Recommended dilution:WB: 1:1000-1:10000; IHC: 1:200-1:1000

Gene ID:

Research Area:Signal Transduction, Immunology, Cancer, Developmental biology, Neuroscience, Stem Cells