NANOS2 Antibody, HRP conjugated - Cat. #: CSB-PA015437LB01HU

SKU: CSB-PA015437LB01HU

Size :50ug

Clone Number:

Aliases:NANO2_HUMAN antibody; Nanos homolog 2 antibody; Nanos homolog 2 Drosophila antibody; NANOS2 antibody; NOS-2 antibody; NOS2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P60321

Immunogen:Recombinant Human Nanos homolog 2 protein (1-138AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NANOS2

Research Areas:Epigenetics and Nuclear Signaling; Developmental biology; Stem cells