N Antibody, HRP conjugated - Cat. #: CSB-PA318492LB01JAM

SKU: CSB-PA318492LB01JAM

Size :50ug

Clone Number:

Aliases:N antibody; Nucleoprotein antibody; EC 3.1.13.- antibody; Nucleocapsid protein antibody; Protein N antibody

Product Type:Polyclonal Antibody

Immunogen Species:Junin mammarenavirus

UniProt ID:P14239

Immunogen:Recombinant Junin mammarenavirus Nucleoprotein protein (1-564AA)

Raised in:Rabbit

Species Reactivity:Junin mammarenavirus

Tested Applications:ELISA

Background:Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation (By similarity). Interacts with host IKBKE (via Protein kinase domain); the interaction inhibits IKBKE kinase activity.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:N

Research Areas:Others