MRPS12 Antibody - Cat. #: CSB-PA788592

SKU: CSB-PA788592

Size :100ul

Clone Number:

Aliases:28S ribosomal protein S12 antibody; 28S ribosomal protein S12 mitochondrial antibody; mitochondrial antibody; Mitochondrial ribosomal protein S12 antibody; MRP-S12 antibody; MRPS12 antibody; MT-RPS12 antibody; RPMS12 antibody; RPS12 antibody; RPSM12 antibody; RT12_HUMAN antibody; S12mt antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O15235

Immunogen:Synthesized peptide derived from internal of Human MRPS12.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein.

Shah Z.H., Gene 204:55-62(1997).
Johnson D.F., Genomics 52:363-368(1998).
Ebert L., Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MRPS12

Research Areas:Epigenetics and Nuclear Signaling;Tags & Cell Markers