Mouse Toll-like receptor 7,TLR7 ELISA KIT

SKU: E0602Mo

Size:96 Tests-1 Kit

Background:Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:21402738). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed:14976261) (By similarity). {ECO:0000250|UniProtKB:Q9NYK1, ECO:0000269|PubMed:14976261, ECO:0000269|PubMed:21402738}.

Research_area:

Applications:ELISA

Target_protein:Tlr7

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.16ng/ml

Detection range:0.38-24ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Toll-like receptor 7

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P58681

MASS(Da):121837

GeneID:170743

Synonyms:Tlr7

Gene names:Tlr7

Standard solution:48ng/ml