Mouse T-cell Surface Glycoprotein Cd4, CD4 ELISA Kit

SKU: E2507Mo

Size:96 Tests-1 Kit

Background:Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II Peptides are derived from extracellular proteins while class I Peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.

Research_area:Others

Applications:ELISA

Target_protein:CD4

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.121ng/mL

Detection range:0.2-70ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:T-Cell Surface Glycoprotein Cd4

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P06332

MASS(Da):51,297

GeneID:12504

Synonyms:CD 4;CD antigen CD4;CD4;T-cell differentiation antigen L3T4;T-cell surface antigen T4/Leu-3;T-cell surface glycoprotein CD4

Gene names:CD4

Standard solution:80ng/mL