Mouse Sphingosine-1-phosphate Lyase 1, SGPL1 ELISA Kit

SKU: E2486Mo

Size:96 Tests-1 Kit

Background:Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (PubMed:9464245, PubMed:20097939). Elevates stress-induced ceramide production and apoptosis (PubMed:9464245). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts (PubMed:20097939, PubMed:28262793). Involved in the regulation of pro-inflammatory response and neutrophil trafficking (PubMed:21173151). Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (PubMed:28521611). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:SGPL1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:3.44ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Sphingosine-1-phosphate lyase 1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8R0X7

MASS(Da):63,677

GeneID:20397

Synonyms:AI428538;D10Xrf45;D10Xrf456;mSPL;S1PL;SGPL1;Sphingosine-1-phosphate aldolase;Sphingosine-1-phosphate lyase 1;Spl;SPL 1;SP-lyase 1

Gene names:Sgpl1

Standard solution:1600ng/L