Mouse Scavenger Receptor Cysteine-rich Type 1 Protein M130, CD163 ELISA Kit

SKU: E2439Mo

Size:96 Tests-1 Kit

Background:Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). After shedding, the soluble form (sCD163) may play an anti-inflammatory role.

Research_area:Immunology

Applications:ELISA

Target_protein:CD163

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:9.61ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Scavenger receptor cysteine-rich type 1 protein M130

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q2VLH6

MASS(Da):120,921

GeneID:93671

Synonyms:CD 163;CD antigen CD163;CD163;CD163v2;CD163v3;Scavenger receptor cysteine-rich type 1 protein M130;sCD163;Soluble CD163

Gene names:Cd163

Standard solution:4800ng/L