Mouse Runt-related Transcription Factor 2, RUNX2 ELISA Kit

SKU: E2438Mo

Size:96 Tests-1 Kit

Background:Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation (By similarity). In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

Research_area:Others

Applications:ELISA

Target_protein:RUNX2

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.526ng/mL

Detection range:1-400ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Runt-Related Transcription Factor 2

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q08775

MASS(Da):66,205

GeneID:12393

Synonyms:Acute myeloid leukemia 3 protein;CBF-alpha-1;Core-binding factor subunit alpha-1;Oncogene AML-3;OSF-2;Osteoblast-specific transcription factor 2;PEA2-alpha A;PEBP2-alpha A;Polyomavirus enhancer-binding protein 2 alpha A subunit;Runt-related transcription factor 2;RUNX 2;RUNX2;SL3/AKV core-binding factor alpha A subunit;SL3-3 enhancer factor 1 alpha A subunit

Gene names:RUNX2

Standard solution:480ng/mL