Mouse Rho Guanine Nucleotide Exchange Factor 1,ARHGEF1 ELISA KIT

SKU: E1357Mo

Size:96 Tests-1 Kit

Background:Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation. Isoform 3 and isoform 4 do not homooligomerize and show an enhanced RhoGEF activity. {ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:8910315}.

Research_area:

Applications:ELISA

Target_protein:Arhgef1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.19ng/ml

Detection range:0.38-24ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Rho Guanine Nucleotide Exchange Factor 1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q61210

MASS(Da):102805

GeneID:16801

Synonyms:Arhgef1 Lbcl2 Lsc

Gene names:Arhgef1

Standard solution:48ng/ml