Mouse R-Spondin-3, RSPO3 ELISA Kit

SKU: E2436Mo

Size:96 Tests-1 Kit

Background:Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis (PubMed:16543246, PubMed:21693646, PubMed:26766444). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:16543246, PubMed:21693646). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (PubMed:26766444, PubMed:16543246, PubMed:21693646). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:RSPO3

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.97ng/L

Detection range:2-600ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:R-spondin-3

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q2TJ95

MASS(Da):31,454

GeneID:72780

Synonyms:2810459H04Rik;AW742308;Cabriolet;Cri;Cristin1;Cristin-1;Cysteine-rich and single thrombospondin domain-containing protein 1;Nucleopondin;Roof plate-specific spondin-3;RSPO3;R-spondin-3;Thsd;Thsd2;

Gene names:Rspo3

Standard solution:640ng/L