Mouse R-spondin-1, RSPO1 ELISA Kit

SKU: E2434Mo

Size:96 Tests-1 Kit

Background:Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes (PubMed: 21693646). Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination (By similarity). Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (By similarity).

Research_area:Developmental Biology

Applications:ELISA

Target_protein:RSPO1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.98ng/L

Detection range:2-700ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:R-Spondin-1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Z132

MASS(Da):29,332

GeneID:192199

Synonyms:Cristin-3;Cysteine-rich and single thrombospondin domain-containing protein 3;mCristin-3;Roof plate-specific spondin-1;RSPO 1;RSPO1;R-spondin-1

Gene names:RSPO1

Standard solution:800ng/L