Mouse Protein Disulfide-isomerase, P4HB ELISA Kit

SKU: E2381Mo

Size:96 Tests-1 Kit

Background:This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP (By similarity). Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307).

Research_area:Others

Applications:ELISA

Target_protein:P4HB

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.053ng/mL

Detection range:0.1-40ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Protein disulfide-isomerase

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P09103

MASS(Da):57,058

GeneID:18453

Synonyms:Cellular thyroid hormone-binding protein;Endoplasmic reticulum resident protein 59;ER protein 59;ERp;ERp59;P4HB;p55;Pd;PDI;Prolyl 4-hydroxylase subunit beta;Protein disulfide-isomerase;Thb;Thbp;

Gene names:P4hb

Standard solution:48ng/mL