Mouse Polycomb Complex Protein Bmi-1, BMI-1 ELISA Kit

SKU: E2018Mo

Size:96 Tests-1 Kit

Background:Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).

Research_area:Cell Biology; Epigenetics and Nuclear Signaling; Stem Cells

Applications:ELISA

Target_protein:BMI1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.022ng/ml

Detection range:0.05-30ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Polycomb complex protein BMI-1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P25916

MASS(Da):36,708

GeneID:12151

Synonyms:BMI 1;BMI1;Polycomb complex protein BMI-1;Polycomb group RING finger protein 4

Gene names:BMI1

Standard solution:32ng/ml