Mouse Phospholipidase A2, PL-A2 ELISA Kit

SKU: E0267Mo

Size:96 Tests-1 Kit

Background:Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (By similarity). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (PubMed: 10066760). Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis (By similarity). Has anti-helminth activity in a process regulated by gut microbiota (PubMed: 29024642). Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (PubMed: 29024642).

Research_area:Others

Applications:ELISA

Target_protein:PLA2G1B

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.223ng/mL

Detection range:0.5-150ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Phospholipidase A2

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Z0Y2

MASS(Da):16,290

GeneID:18778

Synonyms:Group IB phospholipase A2;Phosphatidylcholine 2-acylhydrolase 1B;Phospholipase A2;PLA2G1B;PLA2-Ib

Gene names:PLA2G1B

Standard solution:160ng/mL