Mouse Parathyroid Hormone Related Protein, PTHRP ELISA Kit

SKU: E2329Mo

Size:96 Tests-1 Kit

Background:Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath. Osteostatin is a potent inhibitor of osteoclastic bone resorption.

Research_area:Others

Applications:ELISA

Target_protein:PTHrP

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:8.98ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Parathyroid Hormone Related Protein

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P22858

MASS(Da):20,100

GeneID:19227

Synonyms:Osteostatin];Parathyroid hormone-like protein;Parathyroid hormone-related protein;PLP;Pt;PTH-l;PTH-like;Pthrp;PTH-rP;

Gene names:Pthlh

Standard solution:4800ng/L